Goliath is almost a given, but will anyone else try and stop Demona from acquiring the Soul Edge?
I'd say if you have Demona pursuing Soul Edge you should have MacBeth in there. Either competing with her, he went after Excalibur after all or, if he learned his lesson then, trying to stop her from getting Soul Edge.
Should other Vampire Slayers appear beyond cameos?
Short answer, no. Longer answer, I'm not sure you need two Slayers from the Buffy'verse much less more. I'd go with one Buffy'verse Slayer out to destroy Soul Edge eventually facing Blade for a throw down over whether destroying Soul Edge or vampires is more important.
Who should battle who? What Destined Battles should be touched upon?
Well, there are same canon pairs there people might expect you to do like Ash vs Deadite Ash or Witchblade vs Darkness. I already mentioned I'd skip Buffy vs Faith and go with Buffy vs Blade. I also mentioned that I'd personally expect if not outright Demona vs MacBeth at least MacBeth being present in the story. *Looks at list trying to pick out some more x-over versus that look like they might work.* The Magdalena, if she might not recognize Hellboy is a good guy right off might throw down with him. Yaut'ja Hunter vs Teal'c might reinforce Teal'c's believe the Soul Edge is Alien Technology. The Ravager seeking redemption vs Go-Go Yubari seeking revenge might work. Duncan MacLeod vs Captain Jack Sparrow, and/or Captain Jack Sparrow vs Cervantes could be a lot of fun. That's it for me on the idea front this morning. Hope something in there was helpful.
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I'd say if you have Demona pursuing Soul Edge you should have MacBeth in there. Either competing with her, he went after Excalibur after all or, if he learned his lesson then, trying to stop her from getting Soul Edge.
Should other Vampire Slayers appear beyond cameos?
Short answer, no. Longer answer, I'm not sure you need two Slayers from the Buffy'verse much less more. I'd go with one Buffy'verse Slayer out to destroy Soul Edge eventually facing Blade for a throw down over whether destroying Soul Edge or vampires is more important.
Who should battle who? What Destined Battles should be touched upon?
Well, there are same canon pairs there people might expect you to do like Ash vs Deadite Ash or Witchblade vs Darkness. I already mentioned I'd skip Buffy vs Faith and go with Buffy vs Blade. I also mentioned that I'd personally expect if not outright Demona vs MacBeth at least MacBeth being present in the story. *Looks at list trying to pick out some more x-over versus that look like they might work.* The Magdalena, if she might not recognize Hellboy is a good guy right off might throw down with him. Yaut'ja Hunter vs Teal'c might reinforce Teal'c's believe the Soul Edge is Alien Technology. The Ravager seeking redemption vs Go-Go Yubari seeking revenge might work. Duncan MacLeod vs Captain Jack Sparrow, and/or Captain Jack Sparrow vs Cervantes could be a lot of fun. That's it for me on the idea front this morning. Hope something in there was helpful.